If you are researching injectable dermal fillers, you have probably come across Juvéderm Vollure XC and wondered exactly how much hyaluronic acid it contains. It is a fair question, because the amount of hyaluronic acid in a filler directly influences how it behaves under the skin, how long it lasts, and how it feels during and after treatment. The short answer is that each 1 mL syringe of Juvéderm Vollure XC contains 17.5 mg of hyaluronic acid, which works out to a concentration of 17.5 mg per milliliter of gel.
The short answer: 17.5 mg of hyaluronic acid per syringe
Juvéderm Vollure XC is formulated with a hyaluronic acid concentration of 17.5 mg/mL. Because every Vollure syringe is filled with 1 mL of injectable gel, a single syringe delivers 17.5 mg of hyaluronic acid. That places Vollure in the middle of the Juvéderm family: it is more concentrated than Volbella (15 mg/mL) but lighter than Voluma (20 mg/mL) or Ultra XC (24 mg/mL). The concentration matters because it is one of the factors that determines how much volume the gel adds and how it interacts with the surrounding tissue.
What else is inside a Vollure syringe?
Hyaluronic acid is not the only ingredient in the syringe. Juvéderm Vollure XC also contains 0.3% lidocaine (3 mg per mL), a local anesthetic that helps reduce discomfort during the injection. The rest of the formulation is a phosphate buffer that keeps the gel at a physiological pH, along with water. In other words, the gel is a sterile, biodegradable mixture of cross-linked hyaluronic acid, lidocaine, and buffer, with no animal-derived components.
Why the amount of hyaluronic acid matters
Hyaluronic acid is a naturally occurring molecule found throughout the body, especially in skin, joints, and connective tissue, where it binds water and helps maintain volume and hydration. As we age, our natural hyaluronic acid levels decline, which is one reason skin loses fullness and lines like nasolabial folds become more visible. Injectable fillers ｒｅｐｌａｃｅ that lost volume by placing cross-linked hyaluronic acid directly into the treated area. The cross-linking, not the raw concentration alone, is what gives the gel its structure and longevity.
Vollure is built on Allergan's VYCROSS technology, which blends high-molecular-weight and low-molecular-weight hyaluronic acid chains. The result is a smooth, cohesive gel that integrates naturally with facial tissue, causes relatively little swelling, and lasts longer than earlier-generation fillers. In clinical studies, Vollure has been shown to maintain improvement in moderate to severe nasolabial folds for up to 18 months.
How Vollure compares with other Juvéderm fillers
Every Juvéderm product is made of hyaluronic acid, but the concentration, cross-linking technology, and intended use differ from one product to the next. The table below summarizes the key differences.
| Product | HA concentration | Technology | Typical use | Duration |
|---|---|---|---|---|
| Juvéderm Vollure XC | 17.5 mg/mL | VYCROSS | Nasolabial folds | Up to 18 months |
| Juvéderm Volbella XC | 15 mg/mL | VYCROSS | Lips and perioral lines | Up to 12 months |
| Juvéderm Voluma XC | 20 mg/mL | VYCROSS | Cheek augmentation | Up to 24 months |
| Juvéderm Ultra XC | 24 mg/mL | HYLACROSS | Lips and smile lines | Up to 6 months |
What to expect from a Vollure treatment
Juvéderm Vollure XC is FDA approved for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds, in adults over the age of 21. It has been used in Europe since 2013 under the name Juvéderm Volift XC. The gel is injected with an ultrafine needle, and because it contains lidocaine, most patients report only mild discomfort during the procedure.
As with any injectable filler, the most common side effects are temporary and include redness, swelling, bruising, tenderness, and small bumps at the injection site. These typically resolve within a few days. Because Vollure is made of hyaluronic acid, it can be dissolved with hyaluronidase if a patient is unhappy with the result, which is one of the reasons hyaluronic acid fillers are so widely used.
Hyaluronic acid goes far beyond fillers
While most people first hear about hyaluronic acid in the context of dermal fillers, the molecule plays a much broader role in health and beauty. It is a common ingredient in serums, moisturizers, and eye drops, and it is also taken orally as a hyaluronic acid supplement for skin hydration and joint comfort. The hyaluronic acid benefits that make it valuable in fillers, namely its ability to attract and hold water, are the same properties that make it useful in topical and oral products.
For manufacturers of supplements, skincare, and personal-care products, sourcing high-quality hyaluronic acid is essential. Cactus Botanics is a global natural-ingredient manufacturer and supplier that provides botanical extracts, plant-based powders, and branded nutraceutical ingredients, including hyaluronic acid, to customers in more than 190 countries. Its production facilities follow GMP and quality-control standards, with analytical testing to verify ingredient identity and purity, so formulators can build products on a reliable supply chain.
The bottom line
To answer the original question directly: Juvéderm Vollure XC contains 17.5 mg of hyaluronic acid per 1 mL syringe, along with 0.3% lidocaine. That concentration, combined with VYCROSS cross-linking technology, is what allows Vollure to smooth nasolabial folds for up to 18 months while feeling natural under the skin. And whether it is used in a filler, a serum, or a supplement, hyaluronic acid remains one of the most versatile and well-studied molecules in modern skincare and nutrition.
This article is for general information only and is not medical advice. Dermal filler procedures should always be performed by a qualified practitioner. Product claims have not been evaluated by the U.S. FDA, and hyaluronic acid products are not intended to diagnose, treat, cure, or prevent any disease.
