Top 10 Hyaluronic Acid Suppliers, Manufacturers, Wholesalers, and Traders in the USA

BioPure Solutions isn't just a supplier—it's a partner for companies pushing the boundaries of medical innovation. Founded in 2005 in Boston's biotech hub, this FDA-registered manufacturer specializes in pharmaceutical-grade hyaluronic acid, with a focus on injectables and ophthalmic solutions. What sets them apart? Their commitment to ultra-pure formulations: every batch undergoes rigorous testing for endotoxins, heavy metals, and microbial contamination, ensuring compliance with the strictest pharma standards.

While their core clientele includes big-name pharmaceutical companies and research institutions, BioPure also works with emerging biotechs, offering small-batch production for clinical trials. Their product line includes low-molecular-weight HA for wound care and high-molecular-weight variants for joint injections, all produced in a cGMP-certified facility. For businesses prioritizing safety and regulatory compliance, BioPure is a gold standard.

When it comes to hyaluronic acid for skin, ClearGel Labs is a name that resonates with formulators across the West Coast. Based in Los Angeles, this lab has built its reputation on creating HA raw materials tailored for the beauty industry—think serums, moisturizers, and even makeup primers. Their claim to fame? A proprietary fermentation process that yields low-molecular-weight HA, which penetrates deeper into the skin's layers for long-lasting hydration, making it a favorite for brands crafting the best hyaluronic acid serum.

ClearGel also caters to the clean beauty movement, offering vegan-friendly HA derived from bacterial fermentation (no animal byproducts) and cruelty-free testing. Their product range includes HA powders, liquids, and pre-formulated gels, with customizable viscosities to suit different textures—from lightweight serums to rich creams. With Ecocert certification and a focus on transparency (they provide full COA and MSDS for every order), it's no wonder indie skincare brands and major cosmetics labels alike turn to ClearGel.

As the demand for joint health and beauty-from-within supplements surges, NutriHyal Industries has emerged as a go-to for bulk hyaluronic acid. Located in Dallas, this manufacturer specializes in high-purity HA powders and liquids designed for dietary supplements, with a focus on bioavailability. Their signature product? A 99.9% pure HA powder that dissolves easily, making it ideal for capsules, tablets, and even drink mixes.

NutriHyal prides itself on consistency, with third-party lab results available for every batch to verify potency and purity. They also offer custom formulations, blending HA with other ingredients like collagen or vitamin C for synergistic benefits. Whether you're a startup launching your first supplement line or a large health food company scaling production, NutriHyal's flexible order sizes (from 1kg samples to 1-ton bulk orders) and competitive pricing make them a practical choice. It's no surprise they're a top pick for brands creating the best hyaluronic acid supplements on the market.

For small to mid-sized brands that need a little bit of everything, CosmoHyal Trading is the ultimate problem-solver. Based in Chicago, this trader sources high-quality HA from trusted global manufacturers (vetting each for GMP and ISO certifications) and distributes it across the US, often alongside complementary ingredients like peptides or antioxidants. Their sweet spot? Low minimum order quantities (MOQs start at just 500g) and the ability to mix and match ingredients in a single order—perfect for indie skincare lines testing new formulations or supplement brands with limited storage space.

CosmoHyal's team includes former formulators, so they don't just sell ingredients—they offer technical support, helping clients choose the right HA grade (e.g., cosmetic vs. nutraceutical) for their needs. With fast shipping (most orders arrive within 3–5 business days) and transparent pricing (no hidden import fees), they've become a lifeline for businesses that can't afford to tie up capital in large bulk orders.

When lives and patient outcomes are on the line, PharmaGrade HA delivers. This Philadelphia-based manufacturer focuses exclusively on medical-grade hyaluronic acid, producing formulations for ophthalmic surgeries (e.g., viscoelastic agents), joint injections for osteoarthritis, and even dermal fillers. Their facility is FDA-registered and cGMP compliant, with a sterile production environment that meets the highest pharmaceutical standards.

What makes PharmaGrade stand out? Their ability to produce HA with ultra-low endotoxin levels (less than 0.1 EU/mg), a critical factor for injectable products. They also offer custom molecular weights, working with researchers to develop HA tailored for specific medical applications—from slow-release joint treatments to biodegradable scaffolds for tissue engineering. While their services come with a premium price tag, the peace of mind that comes with their rigorous quality control is invaluable for medical device companies and biotech firms.

For businesses that need HA in truckload quantities, BulkHyal Supply is the heavyweight champion. Based in Houston, this wholesaler specializes in large-scale distribution, serving industries beyond pharma and cosmetics—think food production (as a moisture retainer in baked goods), textiles (for fabric softening), and even industrial lubricants. Their secret to competitive pricing? Vertical integration: they own their fermentation facilities, cutting out middlemen and passing savings to clients.

BulkHyal offers HA in a range of grades, from technical (industrial use) to cosmetic and nutraceutical, with packaging options to match—55-gallon drums, 2000-liter totes, or bulk bags for powders. They also provide logistics support, coordinating shipping to warehouses across the US and even internationally. While they're not the best fit for small brands, their scalability makes them ideal for companies with high-volume needs looking to reduce per-unit costs.

In a market flooded with synthetic ingredients, SkinScience Extracts is a breath of fresh air for eco-conscious brands. Based in Portland, this supplier specializes in organic hyaluronic acid derived from fermented plant sugars, certified by the USDA and free from pesticides, GMOs, and artificial additives. Their production process is equally green: they use renewable energy and recycle 90% of their water, appealing to brands marketing sustainability.

SkinScience's HA is particularly popular in clean beauty, where transparency and natural sourcing are non-negotiable. Their product line includes organic HA powders, hydrating serums-in-a-bottle (ready-to-use bases for small brands), and even organic HA-infused sheet mask solutions. They also offer private labeling for startups that want to launch a natural skincare line without investing in formulation from scratch. For brands that want to align with the "clean beauty" movement, SkinScience is a trusted partner.

When a client needs hyaluronic acid yesterday, VitaHyal Distributors delivers—literally. Based in Atlanta, this regional distributor focuses on quick turnaround times for businesses in the Southeast, offering same-day shipping for in-stock items and next-day delivery to most states in the region. Their warehouse stocks a range of HA grades, from cosmetic powders to nutraceutical liquids, making them a go-to for brands facing production delays or last-minute orders.

VitaHyal prides itself on customer service, with a team of account managers available to help with everything from product selection to logistics. They also offer educational resources, like formulation guides for hyaluronic acid for skin and joint supplements, to support small businesses. While their prices are slightly higher than bulk wholesalers, the speed and convenience make them a lifesaver for time-sensitive projects.

PureHyal Manufacturing stands out for its vertical integration: from fermenting the bacteria that produce HA to packaging the final product, every step happens in-house at their Detroit facility. This control allows them to ensure consistency batch after batch, a critical factor for brands that can't afford variability in their formulations. Their client list includes both large corporations and niche brands, drawn to their ability to customize HA to specific needs—whether it's a particular viscosity for a serum or a specific molecular weight for a supplement.

In addition to standard HA products, PureHyal offers contract manufacturing services, helping brands develop custom formulations from scratch. They also invest in R&D, recently launching a stabilized HA variant that has a longer shelf life in water-based products—a game-changer for skincare brands tired of dealing with degradation issues. With ISO 9001 certification and a focus on innovation, PureHyal is a supplier for brands looking to stay ahead of the curve.

EcoHyal Organics is for brands that refuse to choose between efficacy and the planet. Based in Seattle, this supplier produces organic hyaluronic acid using 100% renewable energy (solar and wind) and zero-waste packaging—think compostable bags and recyclable drums. Their HA is derived from fermented sugarcane, a crop that requires minimal water and no pesticides, aligning with the values of eco-conscious consumers.

But EcoHyal doesn't skimp on performance. Their low-molecular-weight HA is a hit with skincare brands, offering deep hydration, while their organic HA powder is a staple in natural joint supplements. They also prioritize fair labor practices, ensuring their production partners receive living wages. For brands that want to tell a sustainability story alongside their product benefits, EcoHyal provides the certifications and transparency to back it up—from carbon footprint reports to supply chain maps.