Raw materials fot Health Industry

Since we launched Myricetin (from Chinese bayberry bark) a year ago, we have seen tremendous scientific interest in further examining its role in human health. The following are very recent -- and compelling -- citations to published papers exploring myricetin's mechanisms of action.

"Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway."Cancer Letters, Volume 308, Issue 2, 28 September 2011, 181-188
"Effects of nitric oxide on reactive oxygen species and antioxidant capacity in Chinese Bayberry during storage" Scientia Horticulturae, Volume 135, 24 February 2012, Pages 106-111
"Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells" Neuropharmacology, Volume 61, Issues 1-2, July-August 2011, Pages 329-335
"Hydroethidine as a probe for measuring superoxide formation rates during air oxidation of myricetin and quercetin" Tetrahedron Letters, Volume 52, Issue 41, 12 October 2011, Pages 5384-5387
"Protective effects of catechin, morin, myricetin, kaempferol, luteolin and naringin on human LDL carbamylation in vitro" Clinical Biochemistry, Volume 44, Issue 13, Supplement, September 2011, Pages S80-S81
As you can see, myricetin from Chinese Bayberry (bayberry bark) is being shown to be a viable nutraceutical in human health.

Myricetin has antioxidant properties and is a useful addition in many antioxidant formulas. It is also a useful addition in condition-specific formulas. For example, earlier in vitro research suggests that myricetin -- in high concentrations -- can modify LDL cholesterol such that uptake by white blood cells is increased.

And although in the US, we are not allowed by FDA to market supplements for cancer, we can market for condition-specific support. With that in mind, there are some interesting studies of myricetin and certain cancers. One Finnish study correlated high myricetin consumption with lowered rates of prostate cancer; another 8-year study found that three flavonols (kaempferol, quercetin, and myricetin) reduced the risk of pancreatic cancer by 23 percent. Another study of 36 flavonoids found that myricetin was the most potent of them in inhibiting metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells.

The following is from the online research portal,
www.phytochemicals.info/phytochemicals/myricetin.php.
Anti-inflammatory: Myricetin has been shown to inhibit the expression of tumor necrosis factor-alpha, a cytokine that promotes the inflammatory response and is involved in inflammatory diseases. Myricetin glucuronide is an inhibitor of lipooxygenase 5-LOX and cyclooxygenases COX-1 and Cox-2.

Heart health: Myricetin and other flavonoids may improve heart health by preventing LDL oxidation and reducing the uptake of oxidized LDL by macrophages.

Blood Sugar Response: Studies showed that myricetin inhibits the uptake of methylglucose by adipocytes, and has been shown to reduce glucose plasma level in diabetic rats.

Brain health: Myricetin may offer benefits to those who are concerned about impaired brain function. Myricetin inhibits ROS production caused by glutamate and reduces glutamate-induced activation of caspase-3. Myricetin may also inhibit beta-amyloid fibril formation in Alzheimer patients.
Myricetin is a flavonoid that is commonly found in natural food sources. Cactus Botanics' myricetin is extracted from the bark, leaves, and roots of the plant Myrica cerifera, and is completely water soluble, which means it makes an excellent source for teas as well.
Cactus Botanics first offered Myricetin 80%, as tested by HPLC, last year. Now, our esteemed research and development experts have expanded the specifications to now include Myricetin 50%, Myricetin 80% and Myricetin 90%.