Evodia
Powder Extract 
Product
Name : Evodia
Powder Extract
Latin Name: Evodia
rutaecarpa
Specification: Evodiamine 5%,10%HPLC
Country of Origin :China
This
herb is thealmost ripe fruit of Evodia rutaecarpa
which is mainly planted in the provinces of Gui-zhou, Guangxi,
Hunan and Yunnan. It is harvested in autumn, dried in sunlight or at a low
temperature, and used unprepared or prepared with decoction of liquorice.
Function
1.
Anti-cancer
It was reported that evodiamine had a marked inhibitory activity on tumor
cell migration in vitro. To extend our study, the effects of evodiamine on
invasion, growth, and metastatic development of colon 26-L5 cells were
examined here. Evodiamine inhibited the invasion of tumor cells into
Matrigel in a concentration-dependent manner, and achieved 70% inhibition
at 10 ug/ml. Treatment of tumor cells with evodiamine for 24 h showed
little effect on tumor growth at concentrations of less than 10 ug/ml,
whereas an over 48-h treatment resulted in a concentration- and
time-dependent inhibition. Pretreatment of tumor cells with 10 ug/ml
evodiamine before inoculation into mice caused 70% reduction in their lung
metastasis formation. When evodiamine at 10 ug/kg was administered into
mice from the 6th day after tumor inoculation, the number of tumor nodules
in lungs was decreased by 48% as compared to control. The inhibition rate
was equivalent to that produced by cisplatin, a potent anti-cancer drug.
Evodiamine did not affect the body weight of mice in the experimental
period, whereas cisplatin caused serious weight loss. These results
suggest that evodiamine may be regarded as a promising agent in tumor
metastasis therapy.
2.
Anti-Obese
Evodiamine,
a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae),
showed vanilloid receptor agonistic activities comparable to capsaicin.
The Chinese literature refers to Evodia fruits as a ”hot nature” herb.
In spite of the similarities in the actions of evodiamine and capsaicin in
vitro, evodiamine has no perceptible taste, including a peppery hot taste.
Therefore, the effectiveness of evodiamine and the extract of Evodia
fruits in preventing obesity on male C3H mice, or male SD rats were
examined. When evodiamine was supplemented at 0.03 % of the diet and fed
to mice for 12 days, the perirenal fat weight became significantly lower
than in the control group. The epididymal fat mass was also decreased in
the evodiamine diet group. When evodiamine was supplemented at 0.02 % in
the form of ethanol extract of Evodia fruits to the high-fat diet and fed
to rats for 21 days, the body weight, the perirenal fat weight, epididymal
fat weight, the levels of serum free fatty acid, total lipids in the
liver, triglyceride in the liver, and cholesterol level in the liver were
significantly reduced as compared with the control diet group.
Furthermore, both lipolytic activity in the perirenal fat tissue and
specific GDP binding in brown adipose tissue mitochondria, as the
biological index of enhanced heat production, were significantly increased
in the evodiamine fed rats. Fasting mice subcutaneously administered 1-3
mg/kg evodiamine showed decreased core body temperature by 1 - 2 oC. This
hypothermic effect was prevented by the pretreatment of intraperitoneally
administered 10 mg/kg capsazepine, a vanilloid receptor antagonist. On the
other hand, food-sated mice subcutaneously administered 1-3 mg/kg
evodiamine showed unchanged core body temperature and increased tail skin
temperature by more than 5 oC, suggesting the increased energy expenditure
by enhanced heat dissipation. In conclusion, we have demonstrated that a
novel non-pungent vanilloid receptor agonist, evodiamine, mimics the
characteristic anti-obese effects induced by capsaicin. Evodiamine would
induce heat loss and heat production at the same time and dissipate food
energy, preventing the accumulation of perivisceral fat and the body
weight increase.
Chemistry
C24H31N3O
